Category: Science / Life Sciences / Neuroscience

Psychiatric Controversies in Epilepsy

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Psychiatric Controversies in Epilepsy addresses controversial clinical issues of the psychiatric aspects of epilepsy. The book explores the reasons behind the poor communication between psychiatrists and neurologists and suggests potential remedies to this important problem, and two chapters are devoted to examining whether psychiatrists and neurologists are properly trained to recognize and treat conditions that both disciplines commonly encounter in clinical practice. Identification of the causes behind the high rate of comorbidity between epilepsy and mood, anxiety, psychotic and attention deficit disorders is given high priority in the volume, and a specific review of the evidence of common pathogenic mechanisms that may be operant in epilepsy and these psychiatric disorders is included. Recently identified bidirectional relationship between mood disorders and epilepsy and its implication in the course and response to treatment of the seizure disorder are also explored. Several chapters are devoted to rectify common misunderstandings of the use of psychotropic drugs in patients with epilepsy, including the use of antidepressant and central nervous system stimulants. Finally, one chapter explores the possibility of organic causes of psychogenic non-epileptic seizures.

  • Compiles into one source the important controversial issues of the psychiatric aspects of epilepsy, which have significant implications in clinical practice
  • Authors are internationally recognized authorities in the field of psychiatric aspects of epilepsy

Epilepsy

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The present volume is intended to be a synopsis of seizure disorders with a goal of describing key studies in animals and humans. The translation of pertinent findings from animal studies to human studies, and to potential human studies will be emphasized. Specific cogent animal studies/results which deserve exploration in human seizure disorders will be detailed. The current rate of translation is estimated to be from 7‐9 years, and the “success” rate of translation was very recently listed as less than one half. The success rate is defined as results in human studies which were predicted in advance by animal studies. Both the time between animal and human attempts plus the success rate need improvement.

Models of Seizures and Epilepsy

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Models of Seizures and Epilepsy, Second Edition, is a valuable, practical reference for investigators who are searching for the most appropriate laboratory models to address key questions in the field. The book also provides an important background for physicians, fellows, and students, offering insight into the potential for advances in epilepsy research as well as R&D drug development. Contents include the current spectrum of models available to model different epilepsy syndromes, epilepsy in transgenic animals, comorbidities in models of epilepsy, and novel technologies to study seizures and epilepsies in animals.

  • Provides a comprehensive reference detailing animal models of epilepsy and seizure
  • Offers insights on the use of novel technologies that can be applied in experimental epilepsy research
  • Edited by leading experts in the field that provide not only technical reviews of these models but also conceptual critiques
  • Comments on the strengths and limitations of various models, including their relationship to clinical phenomenology and their value in developing better understanding and treatments

Neuropathology and Basic Neuroscience

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The United States Congress designated the 1990’s as the “Decade of the Brain” in recognition of the importance of neuroscience to the health and well-being of Americans. It has been suggested that as many as 20% of all patients seeking medical treatment have neurologic problems, either as the presenting complaint or as an associated condition complicating the primary illness. To this end, it is important that physicians understand basic neuroscience principles and nervous system diseases. Of course, this text is not encyclopedic but instead is an outline of the knowledge required of all medical students. Interested students can consult numerous texts that provide comprehensive coverage of the field, including Greenfield’s Neuropathology and the exhaustive 60 + volume Handbook of Clinical Neurology. The information selected for inclusion in this volume of the Oklahoma Notes series remains true to the goal of the whole series-incorporating only that material vital in both the general clinical practice of medicine and to answer questions on the all-important United States Medical Licensing Examination. Roger A. Brumback Richard W. Leech Acknowledgments This text would not have been possible without a great deal of help and support from a number of individuals. We want to thank all those who assisted in our education in neuroscience and neuropathology including: William M. Landau and Philip R. Dodge of the Washington University School of Medicine, Lowell W. Lapham of the University of Rochester Medical Center, and Ellsworth C.

Neuropathology

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Increasing specialisation in pathology reflects the progressive changes in medical practise. The advent of a specialist with a new interest in a hospital or clinic may present the pathologist with a need to extend his or her knowledge to be able to work closely with the clinical practi tioner in order to provide adequate clinical care. Some sub-specialisations are long established, such a one is neu ropathology. However, an exclusive specialist practise is generally con fined to neurosurgical centres and much neuropathology is of necessity, executed by geneni.l pathologists. The areas covered by this volume are those which are commonly managed by the generalist. Professor Adams’ account of how the skull and brain should be examined here will give confidence to many by defining a good technique and the careful description of various kinds of vascular injury lesions resulting from raised intracranial pressure will help to clarify repeated difficulty. More subtle forms of damage are also considered in detail. Professor Weller provides a detailed account of how the central nervous system may be examined in a way which permits all of us to prepare material which will allow adequate investigation of central nervous system disease and the proper examination of peripheral nerves. This chapter will become a “handbook” and will be of interest to those in training and established practitioners. Muscle biopsy is also dealt with; this is an area of investigative concern for many gener alists. The role of that singular neuropathological technique is very clearly emphasized.

Escourolle and Poirier’s Manual of Basic Neuropathology

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Now in its 5th edition, Escourolle and Poirier Manual of Basic Neuropathology continues the tradition of being one of the most respected texts in neuropathology by providing an introduction to the various diseases of the nervous system and their underlying pathology. This thorough, yet concise manual covers the full spectrum of the various categories of neurologic disease, including neoplasia, trauma, vascular disease, and infection, with separate chapters on prion diseases, multiple sclerosis, degenerative disorders, acquired metabolic diseases, hereditary metabolic diseases, congenital malformations, perinatal diseases, skeletal muscle, peripheral nerve, and the pituitary gland. To accurately guide the clinician, the most current techniques in neuropathology are covered in their own chapter at the end of the book. Richly illustrated throughout, with over 700 images of various neuropathogical diagnoses such as tumor, stroke, infection, degeneration, and malformation among others, this new edition of the classic monograph is an easy-to-use manual for any student, researcher, or practitioner seeking basic information on neuropathology. Used for decades in all fields related to the nervous system-including neurology, neurosurgery, psychiatry, neuroradiology, neuroendocrinology, neuropathology, pathology, and neuroscience- Escourolle and Poirier Manual of Basic Neuropathology is regarded at the ‘bible’ of neuropathology. This new version has been completely rewritten and expanded to include important updates in genetics and molecular biology, reflective of the important neuropathological discoveries in those fields over the past decade.This book is a practical diagnostic tool and necessary reading for anyone encountering pathological conditions of the nervous system.

Neuropathology

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Neuropathology, Volume 145, the latest release in the Handbook of Clinical Neurology series, includes all the major topics found in a typical neuropathology text, but differentiates itself by providing a thorough overview of the morphological background of neurological disorders for researchers and clinicians who do not specialize in pathology or its clinicopathological aspects. This volume offers strong coverage of brain imaging and advances in molecular pathology and genetics, and is particularly timely given the amount of neuropathological research currently taking place.

  • Provides a resource for the non-pathologist, aiding primary clinicians and researchers in the interpretation of patient symptoms and research findings
  • Includes standard neuropathology, but extends to clinicopathology, imaging and molecular pathology/genetics
  • Presents an interdisciplinary approach that can be applied in everyday clinic and research efforts

Forensic Neuropathology

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Forensic Neuropathology provides superior visual examples of the more commonly encountered conditions in forensic neuropathology and answers questions that arise regarding neuropathological findings. The work includes values for frequently-encountered clinical assessments, and contains a more comprehensive summary of aging/dating of various neuropathological processes than is available in any other single current source. General pathology residents, forensic pathology and neuropathology fellows, and general pathologists and clinicians involved in referred cases will find this book extremely useful, as will individuals in allied fields such as law enforcement officers and attorneys.

Forensic Neuropathology aims to: (1) provide a concise summary of practical information frequently needed in forensic neuropathology cases; (2) include selected material previously known but perhaps not significantly emphasized in current literature; and (3) where possible, to suggest aging/dating parameters for certain neuropathological findings relevant to forensic neuropathology testimony. As a selective reference, the volume emphasizes practical issues and focuses on the most commonly encountered issues among neuropathology and medical examiner professionals.

  • Over 800 high-quality full-color photographs, gross and microscopic as well as illustrative line drawings
  • Use of actual cases, briefly summarized and illustrated to emphasize key principles
  • Focuses on the most-commonly encountered cases as relate to forensic incident and covers these aspects in depth and detail

Neurophysiology in Neurosurgery

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Through real-time assessments of how the patient’s nervous system is functioning throughout a surgical procedure, Neurophysiology in Neurosurgery presents vital techniques to guide surgeons in their efforts to minimize the risks of unintentional damage to healthy nervous tissue. This book provides a comprehensive overview of the most up-to-date intraoperative neurophysiological techniques and guidelines for the managment of neuroanesthesia during MEP monitoring. Neurophysiology in Neurosurgery is a valuable educational tool that describes the theoretical and practical aspects of intraoperative monitoring through example.

Neurophysiology in Neurosurgery is a valuable educational tool that describes the theoretical and practical aspects of intraoperative monitoring through example. The authors provide in-depth descriptions of the most advanced techniques in intraoperative neurophysiological monitoring and guidelines for the management of neuroanesthesia during MEP monitoring.

Cellular and Molecular Neurophysiology

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Cellular and Molecular Neurophysiology, Fourth Edition, is the only up-to-date textbook on the market that focuses on the molecular and cellular physiology of neurons and synapses. Hypothesis-driven rather than a dry presentation of the facts, the book promotes a real understanding of the function of nerve cells that is useful for practicing neurophysiologists and students in a graduate-level course on the topic alike.

This new edition explains the molecular properties and functions of excitable cells in detail and teaches students how to construct and conduct intelligent research experiments. The content is firmly based on numerous experiments performed by top experts in the field

This book will be a useful resource for neurophysiologists, neurobiologists, neurologists, and students taking graduate-level courses on neurophysiology.

  • 70% new or updated material in full color throughout, with more than 350 carefully selected and constructed illustrations
  • Fifteen appendices describing neurobiological techniques are interspersed in the text