Category: Medical / Pathology

Light And Electron Microscopic Neuropathology of Slow Virus Disorders

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Light and Electron Microscopic Neuropathology of Slow Virus Disorders provides extensive coverage of the neurobiology and neuropathology of slow, unconventional virus disorders also known as prion diseases. The book features an outstanding group of contributers, including Nobel Laureate Dr. D. Carleton Gajdusek and his co-workers. Studies range from the classical to the modern and are based on light microscopy, electron microscopy, and immunohistochemistry. Specific topics covered include spongiform encephalopathies and the hypothesis of infectious polypeptides, structure of the agent, neuropathology of kuru, Creutzfeldt-Jakob disease, Gerstmann-Sträussler-Scheinker diseases, scrapie, bovine spongiform encephalopathy, and chronic wasting disease. Many chapters are based on findings from over 15,000 unpublished micrographs from cases and experimental models. The book also features an extensive list of references ranging from classic 19th century studies to studies through mid-1992.
Light and Electron Microscopic Neuropathology of Slow Virus Disorders will be an excellent reference for neurologists, neuropathologists, virologists, neurobiologists, and other scientists interested in these virus disorders.

Neuropathology

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Increasing specialisation in pathology reflects the progressive changes in medical practise. The advent of a specialist with a new interest in a hospital or clinic may present the pathologist with a need to extend his or her knowledge to be able to work closely with the clinical practi tioner in order to provide adequate clinical care. Some sub-specialisations are long established, such a one is neu ropathology. However, an exclusive specialist practise is generally con fined to neurosurgical centres and much neuropathology is of necessity, executed by geneni.l pathologists. The areas covered by this volume are those which are commonly managed by the generalist. Professor Adams’ account of how the skull and brain should be examined here will give confidence to many by defining a good technique and the careful description of various kinds of vascular injury lesions resulting from raised intracranial pressure will help to clarify repeated difficulty. More subtle forms of damage are also considered in detail. Professor Weller provides a detailed account of how the central nervous system may be examined in a way which permits all of us to prepare material which will allow adequate investigation of central nervous system disease and the proper examination of peripheral nerves. This chapter will become a “handbook” and will be of interest to those in training and established practitioners. Muscle biopsy is also dealt with; this is an area of investigative concern for many gener alists. The role of that singular neuropathological technique is very clearly emphasized.

Pediatric Neuropathology

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Neuropathology is the foundation for understanding developmental neuroscience, pediatric neurology, and neurosurgery, but until now a comprehensive volume covering all aspects of pediatric neuropathology was not available. This atlas is thus a unique, comprehensive reference providing the fundamentals of developmental brain disorders of the nervous system that can affect fetuses, infants and young children, as well as the essentials of diagnosis in developmental brain pathology and neuroimaging. With an emphasis on the characteristic morphology and a concise summary of clinical features, pathogenesis, and genetics, the generously illustrated atlas presents more than 100 disorders, including the common diseases of the peripheral nervous system as well as genetically determined metabolic and storage diseases. This compilation is a valuable resource for pathologists, pediatric neurologists and neurosurgeons, geneticists, neonatologists, radiologists, and pediatricians.

Neuropathology

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In commissioning this volume of Current Topics in Pathology, the editor of the series, Prof. Sir Colin Berry, asked me to produce something “which is aimed at the general pathologist but from the point of view of the neuropathologist who knows what is not being done well”. This was easier said than done. Many aspects of neuropathology are encountered only infrequently in general pathology and are best dealt with by re ferral of material to a specialist unit. Others need more extensive investigation than is practicable in a general pathology setting. Yet neurological disorders in general are common and are encountered by general histopathologists, paediatric and forensic pathologists on a daily basis, particularly in autopsy practice. In inviting contributions to this volume of Current Topics in Pathology, I therefore biased the con tents towards disorders in which the conduct of the autopsy and the initial approach to neuropathological investigation are of critical importance in making the diagnosis. The authors all have a wealth of experience and expertise and I believe that this is reflected in their approach, which is both personal and practical. Indeed, the emphasis in this book is very much on the provision of practical advice. All of the chapters contain guidelines on the conduct of autopsies as well as infor mation on the macroscopic and basic histological assessment of the nervous system in the relevant disorders.

Neuropathology,A Volume in the High Yield Pathology Series (Expert Consult – Online and Print),1

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Save time diagnosing neuropathology specimens with Neuropathology, part of the growing High-Yield Pathology Series. Dr. Anthony Yachnis and Dr. Marie Rivera-Zengotita help you review the key features of neuropathology specimens, recognize the classic look of each disease, and quickly confirm your diagnosis. A logical format, excellent color photographs, concise bulleted text, and authoritative content will help you accurately identify hundreds of discrete disease entities.

Find information quickly and easily with a templated, easy-to-reference format and concise, bulleted text.Confirm your diagnoses with superb color photographs that demonstrate the classic appearance of each disease. Depend on authoritative information from leading experts in the field.Access the full text online, perform quick searches, and download all the images at www.expertconsult.com.

Neuropathology of Epilepsy

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The multi-authored book intends to describe the neuropathological appearances associated with epilepsy in childhood and in adults and is based on personal experience of authors working at institutions in the UK and USA who have a strong commitment with epilepsy. The literature on the subject is reviewed. Special emphasis is given to correlations between physical signs and symptoms, radiological presentation, suitability to various operative procedures and pathological findings. The book will include chapters by physicians, physiologists, radiologists, neurosurgeons, all with special interest in the field of epilepsy. The description of the pathological features will include immunohistochemical data as well as results of morphometric analysis.

Intra-Operative Neuropathology for the Non-Neuropathologist

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This volume acquaints the non-neuropathologist with the advantages of clinical-radiologic-pathologic correlation in neuropathology specimens, particularly in the intra-operative consultation. As a good cytology preparation can add to, or even supply in isolation, a diagnosis, this volume covers the enormous and sometimes insurmountable artifacts involved with freezing tissue, especially central nervous system tissue. The text presents how to perform, and stain the cytologic preparations, and how to interpret them. The advantages and disadvantages of both frozen sections and cytologic preparations of various kinds are discussed. The presentation and format is very visual with diagrams, tables, with many figures including pearls and pitfalls and therefore easy reading.

An introductory chapter presents the pros and cons of cytology, the advantages and disadvantages of frozen sections, and the artifacts in both. Also included is an argument for knowing what the scans reveal, and the impact of relevant patient history. The volume uses a case-based approach to show correlation between scan, history, frozen section and cytologic preparations.

With the combination of extensive correlation of scans, cytology, and frozen section with differential diagnosis, and analysis of the information crucial to the neurosurgeon in a case-based approach and with a special chapter written by a neuroradiologist, this volume is unique in presentation and utility and will be of great value to the trainee in pathology (residents/fellows), and practicing pathologists who include neuropathology in their practice, but do not have formal fellowship training in neuropathology.

Escourolle and Poirier’s Manual of Basic Neuropathology

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Now in its 5th edition, Escourolle and Poirier Manual of Basic Neuropathology continues the tradition of being one of the most respected texts in neuropathology by providing an introduction to the various diseases of the nervous system and their underlying pathology. This thorough, yet concise manual covers the full spectrum of the various categories of neurologic disease, including neoplasia, trauma, vascular disease, and infection, with separate chapters on prion diseases, multiple sclerosis, degenerative disorders, acquired metabolic diseases, hereditary metabolic diseases, congenital malformations, perinatal diseases, skeletal muscle, peripheral nerve, and the pituitary gland. To accurately guide the clinician, the most current techniques in neuropathology are covered in their own chapter at the end of the book. Richly illustrated throughout, with over 700 images of various neuropathogical diagnoses such as tumor, stroke, infection, degeneration, and malformation among others, this new edition of the classic monograph is an easy-to-use manual for any student, researcher, or practitioner seeking basic information on neuropathology. Used for decades in all fields related to the nervous system-including neurology, neurosurgery, psychiatry, neuroradiology, neuroendocrinology, neuropathology, pathology, and neuroscience- Escourolle and Poirier Manual of Basic Neuropathology is regarded at the ‘bible’ of neuropathology. This new version has been completely rewritten and expanded to include important updates in genetics and molecular biology, reflective of the important neuropathological discoveries in those fields over the past decade.This book is a practical diagnostic tool and necessary reading for anyone encountering pathological conditions of the nervous system.

Neuropathology Review

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The scope of neuropathology continues to expand and the ever-increasing amount of information to assimilate and master can be daunting. Neuropathology Review, Second Edition summarizes in simple outline form the essentials of neuropathology. It has been updated to reflect the newest information and ideas in this constantly changing field.

Principles and Practice of Neuropathology

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From reviews of the First Edition: “Being a concise introduction to the principles of neruopathology is a goal this book accomplishes admirably.” Annals of Neurology; “unquestionably valuable as a reference text” Arch Path Lab Med; “a fine treatise which truly reflects the current knowledge of the discipline with a strong emphasis on morphologic aspects” Brain Pathology; “an excellent current reference work on neuropathology for practitioners in the various clinical and basic neurosciences” Journal of Neuropathology and Experimental Neurology.